Early Acute Kidney Injury in Preterm and Term Neonates: Incidence, Outcome, and Associated Clinical Features

<b><i>Background:</i></b> Critically ill neonates are at high risk of kidney injury, mainly in the first days life. Acute injury (AKI) may be underdiagnosed due to lack a uniform definition. In addition, long-term renal follow-up is limited. <b><i>Objective:</i></b> To describe incidence, etiology, and outcome developing AKI within week after birth cohort NICU-admitted between 2008 2018. Renal function discharge infants with early was assessed. <b><i>Methods Subjects:</i></b> defined as an absolute serum Cr (sCr) value above 1.5 mg/dL (132 μmol/L) 24 h or stage 2–3 NIDDK neonatal Clinical data outcomes were collected from medical records retrospectively analyzed. <b><i>Results:</i></b> From January December 2018, total 9,376 admitted NICU Wilhelmina Children’s Hospital/UMC Utrecht, whom 139 diagnosed during birth. 72 term infants, most common etiology perinatal asphyxia (72.2%), followed by congenital urinary tract malformations (CAKUT) (8.3%), heart disease (6.9%), sepsis (2.8%). Associated conditions 67 preterm treatment hemodynamic significant PDA (27.2%), ­CAKUT (21%), (19.4%). Among asphyxia, sCr >1.5 criterion. improved 76 associated acquired conditions. Neonates 3 showed increased values discharge. Half these caused evolved into chronic (CKD) later Neurodevelopmental (NDO) 2 years favorable 93% surviving detailed follow-up. <b><i>Conclusion:</i></b> During birth, seen 1.5% level III NICU. had but not AKI. Long-term needs further exploration, whereas NDO appears good.